Fibromyalgia is a musculoskeletal disorder with symptoms such as fatigue, chronic and diffuse pain, cognitive impairment, and sleep difficulties. It can affect people of any age and gender, although adult women seem to be most affected. The complexity of the disorder can make it difficult to diagnose and treat. Acupuncture can be a good pain management option for fibromyalgia patients, as it stimulates natural pain-relieving mechanisms in the body and has little to no side effects. A 2018 trial suggested that acupuncture causes changes in the levels of two neurotransmitters (brain chemicals) that are key to fibromyalgia. Acupuncture appears to increase serotonin and decrease substance P, which can improve fibromyalgia symptoms.