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Gender Differences in Metabolism

Women appear to be more vulnerable than men to the many adverse consequences of alcohol which may include alcohol related organ damage, trauma, and legal consequences. At every age there are a number of reasons for these differences.

Body Water: Women’s bodies contain proportionately less water and more fat than a men’s. Water dilutes alcohol and fat retains it, so organs are exposed to higher concentrations of alcohol for longer periods of time. At any given dose, our blood alcohol levels will be higher than a man’s, even taking into account differences in body weight. As a result one drink for a woman is roughly equivalent to two drinks for a man. As women age their bodies contain even less water and more fat, so blood alcohol
Levels rise even faster

Less Enzymes in Stomach, Small Intestine and Liver: Males and females differ in their ability to metabolize alcohol. Women absorb and metabolize alcohol differently than men. This difference is due to variations in the amount of the enzyme responsible for metabolizing alcohol. Women have less of this enzyme in their stomach, small intestine and liver. As 30% of alcohol goes through the stomach directly into the blood stream this means that the alcohol goes through the bloodstream to all cells of the body less diluted and in higher concentrations.

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