Acupuncture has shown promising potential in addressing cognitive decline. By improving cerebral blood flow, it enhances oxygen delivery and reduces stress hormones like cortisol while increasing serotonin, dopamine, and acetylcholine—specifically linked to memory. Acupuncture also promotes cholinergic and dopaminergic neural transmission, facilitates neurotrophin signaling and nerve growth factor, and protects cerebral neurons from apoptosis and oxidative damage. Furthermore, it regulates glucose metabolism, suppresses acetylcholinesterase, and decreases levels of amyloid beta proteins in the brain regions associated with cognitive decline. Research suggests that combining acupuncture with drug therapy may be more beneficial for individuals with Alzheimer’s disease than drug therapy alone, highlighting its complementary role in Western medicine.