Knee pain caused by osteoarthritis or injury can have a negative impact on quality of life, reducing mobility and getting in the way of your daily activities. One study of 18,000 patients found acupuncture to be helpful for many pain conditions, including knee osteoarthritis. When the acupuncture needles are placed on the body, a signal is sent along the spinal cord to the brain which may trigger a release of endorphins, helping to reduce pain. Acupuncture also may decrease the production of cortisol in the body, a hormone that helps control inflammation. With reduced pain sensations and less inflammation, knee function and mobility can be improved.