IBS is diagnosed using the Rome Criteria, based on symptom patterns rather than inflammation. Unlike Crohn’s or colitis, IBS lacks inflammatory markers, making it a diagnosis of exclusion. New tests, like anti-CdtB and anti-vinculin antibodies, link IBS to past infections. Breath tests and stool analysis detect microbial imbalances and enzyme deficiencies. These advancements shift IBS care from symptom management to root-cause treatment, enabling personalized, targeted therapies for lasting relief.

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