What is the best diet strategy for weight loss? The answer depends on your weight loss goals. Unfortunately, the evidence is conflicting about what strategies work best. At the end of the day, the best diet for you is the one that you can faithfully follow for a lifetime to help you to reach your optimal weight and allows you to not feel hungry or deprived. Medications can also contribute to weight gain, so have a pharmacist review your medications to ensure a medication is not contributing to unwanted weight.