To keep your dentures clean, soak them at least once a day. Products available in stores aren’t always strong enough to fight plaque and residue buildup, so try using a professional strength cleaner a couple of days a week, and a weaker store-bought cleaner on the other days. Never use toothpaste on dentures, as it can take the finish off and is only designed for natural teeth. Soaking your dentures softens the residue, but it is still very important to brush them with a denture brush afterwards. Always follow the instructions included with your cleaner to avoid damaging your dentures.