Place a towel in or fill the sink with water to avoid breaking your dentures. Brush your gums, cheeks, and tongue with a soft toothbrush after removing the dentures. Gently clean your dentures daily (do not sleep with your dentures in). Soak and brush them with a soft-bristled brush and nonabrasive denture cleanser (not toothpaste) to remove food and plaque. Don’t use denture cleansers inside your mouth. Place the dentures in water or a mild denture-soaking solution overnight. If you use a denture cleaner overnight, it is very important to rinse the dentures thoroughly before placing them back into your mouth.