Are your dentures irritating your gums? If your dentures do not fit properly, they can chafe the gums, causing irritation. Tissue irritation can make your dentures so uncomfortable, it’s practically impossible to wear them because of the pain. Practice good oral hygiene habits. Remove your dentures every night and use a soft-bristled brush to brush your gums, tongue, cheeks, and the roof of your mouth. Maintain regular checkups with your denturist and if your dentures become loose, have them looked at as soon as possible. Loose dentures can cause irritation that can lead to sores and infection.