If you get migraine headaches often, you may wonder if there’s anything you can do to prevent them. Botox was approved in 2010 for adults who get chronic migraines. Botox works by blocking chemicals called neurotransmitters that carry pain signals from your brain. Botox is like a roadblock in that pathway. It stops the chemicals before they get to the nerve endings around your head and neck. Studies have shown that Botox cut down the total number of days migraine sufferers have headaches. They also have more “crystal-clear” – pain-free – days each month, and they report fewer days off work.