Vitamin C is essential for brain health. However, only an extremely small portion of the nutrient’s molecules ingested are conveyed into the organ. In 2014, biochemists in South Korea found high-dose vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brains of mice with genetically engineered Alzheimer’s disease. If you want to get more vitamin C accumulated in your brain, do high-dose supplementation or take regular vitamin C supplements. The latter method is likely better, as high-dose supplementation can cause adverse effects, according to some medical researchers.